Monday, September 24, 2012

How long does it take for a HCG shot (pregnyl) to leave your system?

I saw this question posted in several forums and blogs and decided to write about my experience with it. I know that during our 2 weeks wait we are always obsessing to know if we are getting a real BFP and I hope my experience can help someone looking for a little comfort.


I took HCG shots to trigger my ovulation in all 4 IUIs. The doctors would say that I could only have a beta at least 14 days after the HCG shot to avoid false positives. I don’t remember how much was the dose but 7 after the shot I would have negative urine tests. There was this once when I had a blood test exactly 14 days after my shot and it came back inconclusive. I don’t really know if it was a chemical or traces of the shot because the next day AF arrived. 

During my last IVF cycle I had not only a HCG trigger shot but I also had a second shot in the middle of the 2 week wait as a booster (5000 iu). 5 days after the booster (15 dpo or 13dp2dt ) my doctor asked for a beta. I couldn’t really understand why he would ask me to have a blood test when it would be probably a deceiving result. My beta was 28. He said that it was probably negative because by this time if there was a healthy embryo and it had implanted I should have at least a beta of 50-60. He also said that I probably had an implantation but it didn’t take because if it was only traces of the shot I would have a beta with less than 16. 

I don’t know if I believe him or not. He probably has more experience than I do with all this hormone craziness. I read that it takes 1 day per 1000 iu for the HCG shot leave your system. Obviously, in my case 5 days after the shot I still had HCG in my blood stream. I would say that testing only 2 weeks after is being too cautious but testing 5 days later is maybe too early. The doctor told me then to stop all the shots (yay!) and wait for my period :( AF has not shown it ugly face yet but I’ve been testing at home and the line gradually disappeared around 7-8 days after the shot. 

To conclude, I think everyone is different and it probably depends on your weight, if you drink lots of liquids after the shot, the dose administrated and etc. My experience says my body takes a week to excrete the whole 5000 IU Pregnyl shot. I do believe if you have a HCG trigger and a week later you have a positive stick in your hand or if you faint line gets darker the following days you are probably looking at the real thing. 

19 comments:

  1. I've had some strange experiences with the hcg shot. My first IUI cycle I had a 10,000 iu shot, and got a positive HPT 15 days after the shot and a negative beta at 16 days past, my second IUI I also had a 10,000 iu shot and I had a blaringly positive hpt 18 days after the shot, and a negative beta the same day. It's strange and I'm not sure if I had chemicals or if hcg just takes a really long time to leave my system. Hugs to you since I know how frustrating a result like that can be, and I'm sorry that (it looks like) this cycle didn't work out.

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  2. Thank you Lisa! From what I've read it could be both. I had an inconclusive result 14 days after my 3rd. IUI. Still, I would think that the shot wouldn't last in your system for 18 days. The instructions on the drug says that less than 10% of the drug will remain in your system (5 days later). The liver metabolize it and I also read if you drink lots of water you will excrete it faster.

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  3. I agree with you on the amount of time it takes to get rid of the hcg--in my experience, it took me about 7 days as well. I guess everyone is different though--I've known people it took about ten days or more. I think it has something also to do with how fast your body metabolizes the hormone. Either way, it is always a tricky thing testing after a trigger shot!

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